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Research Summary: Particulate Matter

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Piers MacNaughton, ScD, Harvard T.H. Chan School of Public Health
Kevin Lane, PhD, Boston University School of Public Health

What is it?

Particulate matter refers to liquid and solid particles that are suspended in the air. In one cubic centimeter of air, there are typically over 5,000 of these particles. Particulate matter is comprised of a variety of compounds from both natural and anthropogenic sources. The toxicity of particulate matter depends on its composition; natural substances such as sand tend to be larger and benign while anthropogenic compounds such as those emitted from automobiles and power plants tend to be more toxic. Anthropogenic particles are a combination of compounds that are directly emitted by power plants and mobile sources such as black carbon and polycyclic aromatic hydrocarbons (PAHs) and particles that form through chemical reactions with gaseous compounds emitted into the atmosphere such as sulfur dioxide (SO2), nitrogen oxides (NOx ), and volatile organic compounds (VOCs). Natural and anthropogenic particles have different size distributions as well, with anthropogenic particles generally being smaller.1 For this reason particulate matter is often characterized by its size. PM10 refers to particles less than 10 μm in diameter, PM2.5 for particles less than 2.5 μm in diameter and so on. Concentrations of particulate matter are reported in units of particle mass or particle counts, the former usually being in units of micrograms of particulate matter per cubic meter of air and the latter being the number of particles per cubic centimeter of air.2 As smaller particles tend to be more numerous, particle counts are predominantly an indicator of ultrafine particles (UFP), or particles with a diameter less than 0.1 μm.

The toxicity of particulate matter depends on its composition; natural substances such as sand tend to be larger and benign while anthropogenic compounds such as those emitted from automobiles and power plants tend to be more toxic.

Why do we care?

Humans have evolved to have several layers of protection from respirable hazards. The first is the hair-like vibrissae and mucus in the nasal cavity, which filter particles out of incoming air, and the second is the blood-air barrier in the alveolar region of the lungs, which serves to exchange fresh oxygen with CO2 in the blood and prevents most other compounds from entering the blood stream. Larger particles, such as those that come from natural sources, are filtered out through the nasal passage, but particles smaller than 2.5 microns in diameter can penetrate into the lungs.3 Once there, they can cause a host of respiratory ailments including asthma, respiratory inflammation, decreased lung function and cancer.4-6 These damages are caused by two main pathways: 1) free radicals and free radical precursors (such as heavy metals and PAHs) in PM2.5 can lead to oxidative stress of the lung tissues7-10 and 2) the inflammatory response in reaction to PM2.5 can over time lead to irreparable damages in lung function.11-13 The magnitude of the health burden from exposures to PM2.5 became apparent in the landmark Six Cities study, which found mortality rates increased by 16% for every 10 μg/m3 increase in PM2.5 concentration.14 For reference, the National Ambient Air Quality Standard (NAAQS) regulating PM2.5, which was enacted shortly after the six cities study, is 12 μg/m3 while the average concentration in Beijing since 2008 is approximately 100 μg/m3 . 15 Studies published since the Six Cities study have related PM2.5 to a host of pulmonary and cardiovascular diseases.5,16-18

Of increasing concern are UFP, which not only can penetrate to the alveolar region of the lungs but also are small enough to pass through the blood-air barrier and enter the blood stream.19-22 Recent research suggests that the impacts of PM2.5 may be driven in part by the particles on the small end of the size distribution. UFP, as measured by particle counts, have been linked to inflammatory markers in the blood, which are a precursor for cardiovascular disease.23-27

In a study of six U.S. cities, mortality rates increased by 16% for every 10 μg/m3 increase in ambient PM2.5 concentration.14

How does the building contribute to this issue?

Buildings can both exacerbate and attenuate particulate concentrations indoors. Mechanically ventilated buildings typically have filters in the heating, ventilation and air conditioning (HVAC) systems that collect particles from outdoor air entering the building. Filters are rated on a minimum efficiency reporting value (MERV) scale ranging from 1 to 20. Filters with higher MERV ratings remove smaller and a higher percentage of particles. For example, a MERV 14 filter will remove between 75-85% of particles in the 0.3-1 μm diameter range and over 90% of larger particles. HEPA filters are MERV 17-20 and remove 99.97% of particles greater than 0.3 μm in diameter.28

Buildings are also home to many indoor sources of particulate matter, which can lead to higher levels indoors than out. Gas stoves generate combustion byproducts during cooking that cause dramatic spikes in particulate concentrations.29 Other common indoor sources include personal care products, candles, incense and smoking. These indoor sources are most prevalent in residential environments, which are also more likely to be naturally ventilated (i.e. without filtration) than commercial buildings. In a study of two residential apartment buildings in the US, apartments with combustion sources had an average PM2.5 concentration of 94 μg/m3 compared to 53 μg/m3 in apartments without. The building that was mechanically ventilated had concentrations that were half of outdoor levels, while the building that was naturally ventilated had concentrations that were 30% higher than outdoor levels.30

What can I do?

PM2.5 is a regional pollutant, where emissions from one state may influence concentrations in another. Therefore, ambient levels of particulate matter must be regulated at the state and national level, and since 2000 average PM2.5 concentrations have fallen from 13.5 μg/m3 to 8.5 μg/m3 in response to the NAAQS.31 While your surrounding context may be out of your control, exposures to particulate matter for residents in the same location differ substantially. In the same building, indoor levels can range from 75% lower than outdoor levels to 60 times larger.30 In mechanically ventilated buildings, you can increase the MERV rating of the filters in your HVAC system to remove a larger percentage of the smaller, more toxic particles. In naturally ventilated spaces, standalone filtration units can provide the same benefit. In residential environments, source control – using electric over combustion cooking appliances, smoking outside the residence, reducing the use of spray products, etc. – can lower concentrations, in particular attenuating peak concentrations. In the case of gas stoves, ventilation hoods can exhaust combustion fumes outside during cooking events. Developers and building managers can investigate proximity to major outdoor sources such as highways and power plants to determine if other control techniques are necessary to manage indoor particulate levels.


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